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Alendronate Sodium (Fosamax®) | ||
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| This illustrates the effect of alendronate 40 mg/day on serum alkaline phosphatase in two randomized double-blind clinical trials. Alendronate was more effective than etidronate in reducing enzyme activity in these studies of patients whose baseline alkaline phosphatase activity was at least two times the upper limit of normal. In 32 patients followed for 1 year after treatment, enzyme activity remained suppressed in 29/32 patients. | |||