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| Follow-up for patients with Paget's disease should include monitoring serum alkaline phosphatase (SAP) annually in untreated patients with mild cases. In treated patients, SAP is usually monitored every 3-4 months. Alternatively, urinary collagen cross-link measurements can be used. Annual x-ray studies should be done when osteolytic disease is present, to determine if treatment has caused healing of the pagetic lesions, or if there is significant progression of the lesions. | |||