1 |
2 |
3 |
4 |
| The Paget
Foundation for Paget's Disease of Bone and Related Disorders |
Portrait of
Sir James Paget |
Paget's First
Patient |
Epidemiology |
5 |
6 |
7 |
8 |
| Bone
Showing Active Lesion of Paget's Disease |
Composite
Sections of Normal and Pagetic Bone |
Section
of Osteoclast Nucleus Containing Measleslike Nucleocapsid |
Radiograph
of a Skull Demonstrates
Osteoporosis Circumscripta |
9 |
10 |
11 |
12 |
Radiograph
of a Femur
|
Radiograph
of a Tibia Demonstrate Severe Osteolytic Activity |
Radiograph
of a Skull Shows Late-Stage Disease |
Magnetic Resonance
Image of a Skull |
13 |
14 |
15 |
16 |
| Computed Tomography
of a Vetebra |
Radiograph
of a Thoracic Spine |
A
Bone Scan Showing Widespread Disease |
Bilateral
Thermogram of a Tibia |
17 |
18 |
19 |
20 |
| Biochemical
Findings in Paget's Disease |
Correlation
Between Biochemical Parameters |
Metabolic
Complicatons of Paget's Disease |
Musculoskeletal
Complications of Paget's Disease |
21 |
22 |
23 |
24 |
| Musculoskeletal
Complications: Pelvic Involvement and Degenerative Arthritis |
Musculoskeletal
Complications: Lower Extremities |
Musculoskeletal
Complications: Fissure Fracture |
Musculoskeletal
Complications: Chalk-Stick Fracture |
25 |
26 |
27 |
28 |
| Neurologic
Complications of Paget's Disease |
Audiogram
of Patient with Paget's Disease |
Ocular
Complications: Fundus of the Eye |
Cardiovascular
Complications of Paget's Disease |
29 |
30 |
31 |
32 |
| Neoplastic
Complications of Paget's Disease |
Neoplastic
Complications of Paget's Disease Related Osteogenic Sarcoma |
Indications
for Treatment of Paget's Disease |
Approved Therapies
for Paget's Disease of Bone in U.S. |
33 |
34 |
35 |
36 |
| Bisphosphonates
Approved for Other Indications or Under Study for Paget's Disease |
Synthetic
Salmon Calcitonin (Miacalcin) |
Chronic Treatment
with Salmon Calcitonin |
Etidronate
Disodium (Didronel® ) |
37 |
38 |
39 |
40 |
| Etidronate
Disodium (Didronel® ) |
Pamidronate
Disodium (Aredia® ) |
Pamidronate
Disodium (Aredia® ) |
Alendronate
Sodium (Fosamax® ) |
41 |
42 |
43 |
44 |
| Alendronate
Sodium(Fosamax® ) |
Tiludronate
Disodium (Skelid® ) |
Tiludronate
Disodium ( Skelid® ) |
Risedronate
Sodium (Actonel
) |
45 |
46 |
47 |
48/49
|
| Risedronate
Sodium ( Actonel
) |
Nonspecific
and Experimental Therapies for Paget's Disease of Bone |
Hierarchy
of Paget's Disease Treatments |
Hip Replacement
for Paget's Disease and Degenerative Arthritis |
50 |
|
|
|
| Patient
Follow-Up |
|
|
|