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Paget's
disease progresses slowly; considerable evidence indicates that a
slow viral infection of bone may be involved. This electron micrograph
shows the nucleus of an osteoclast. The central structure resembles
an array of nucleocapsids of measles virus or other paramyxoviruses.
This is a characteristic lesion often found in the nuclei and sometimes
in the cytoplasm of patients with Paget's disease. Immunostaining
has demonstrated the nucleocapsid antigens of measles virus and respiratory
syncytial virus in most patients with Paget's disease. Measles virus
and canine distemper virus mRNA have been found in some but not all
studies. |
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