Paget Paget
Paget Paget
  Educational Slide Program  
 

  7  
Section of Osteoclast Nucleus Containing Measleslike Nucleocapsid  
 
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  Paget's disease progresses slowly; considerable evidence indicates that a slow viral infection of bone may be involved. This electron micrograph shows the nucleus of an osteoclast. The central structure resembles an array of nucleocapsids of measles virus or other paramyxoviruses. This is a characteristic lesion often found in the nuclei and sometimes in the cytoplasm of patients with Paget's disease. Immunostaining has demonstrated the nucleocapsid antigens of measles virus and respiratory syncytial virus in most patients with Paget's disease. Measles virus and canine distemper virus mRNA have been found in some but not all studies.  
 
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