When the Paget Foundation was founded in 1978 as a national voluntary health agency located in New York, NY, its mission was to provide information on Paget's disease of bone to patients, family members and health professionals. Beginning in 1992, the foundation expanded its mission to include other bone disorders, including primary hyperparathyroidism, fibrous dysplasia, osteopetrosis (not the more common disease osteoporosis) and the effects of certain cancers on the skeleton.

To meet these objectives, the Foundation provides publications on all of these disorders, physician referral lists for Paget's disease, primary hyperparathyroidism, fibrous dysplasia and osteopetrosis, research grants for scientists studying Paget's disease and hyperparathyroidism and educational programs for physicians and scientists.