Paget Paget
Paget Paget
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  17  
Biochemical Findings in Paget's Disease  
 
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  The biochemical findings in Paget's disease reflect the increased rates of bone resorption and bone formation. Urinary hydroxyproline, and, more recently, urinary collagen cross-link excretion correlate with the extent of skeletal involvement and disease activity. Fasting urinary calcium/creatinine may be increased when bone resorption significantly exceeds bone formation. Either total or bone-specific alkaline phosphatase reflects the overall rate of bone formation. Serum osteocalcin is a less sensitive index of disease activity.  
 
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