Paget Paget
Paget Paget
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  36  
Etidronate Disodium (Didronel®)  
 
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  Etidronate, the first therapeutic bisphosphonate, slows accelerated bone turnover in pagetic lesions and, to a lesser extent, in normal bone. Symptomatic relief was reported in three of five patients. The recommended dose is 5 mg/kg/day taken orally once a day on an empty stomach. Patients should not consume food, beverages, or medications for 2 hours before or after taking the drug. A given treatment course of etidronate should not exceed 6 months and should be repeated only after a drug free period of at least 3 months. It has been widely reported that secondary resistance has been observed after repeated courses of treatment.

Source: Meunier, 1991.
 
 
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