Paget Paget
Paget Paget
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Etidronate Disodium (Didronel®)  
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  This figure illustrates the response to 6 months of etidronate treatment in 14 patients with Paget's disease. Both serum alkaline phosphatase activity and urinary hydroxyproline excretion fell by about 50% and were still suppressed at 12 months. Source: Siris, ES, Canfield, RE, Jacobs, TP, Stoddart, KE, Spector, PJ. Clinical and biochemical effects of EHDP in Paget's disease of bone: patterns of response to initial treatment and to long-term therapy. Metab Bone Dis Relat Res 1981; 3: 301-308.  
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