Paget Paget
Paget Paget
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  11  
Radiograph of a Skull Shows Late-Stage Disease  
 
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  The intermediate phase of Paget's disease is characterized by an alteration in osteoclastic activity, that results in an accelerated rate of bone resorption followed by greatly increased osteoblastic activity. As the disease advances, the cortices become coarsely trabeculated and thickened, and the bone broadens and bows. In the late, "sclerotic" phase of Paget's disease, seen here in the skull, bone resorption continues, but overgrowth of bone predominates. The late stage is characterized by a tremendous thickening of the cranial vault with chaotic bone structure. Areas of lytic activity can be noted toward the posterior aspect of the skull. In weight-bearing long bones, this process usually results in structurally weakened bone that has an increased tendency to deform or fracture.  
 
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