Paget Paget
Paget Paget
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  19  
Metabolic Complicatons of Paget's Disease  
 
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  Bone biopsies and biochemical measurements indicate increased cellular and metabolic activity in active Paget's disease. When bone resorption exceeds bone formation, hypercalciuria and/or hypercalcemia may develop. The latter is rare and when it occurs, it is usually in an immobilized patient. In some but not all studies an increased incidence of primary hyperparathyroidism has been reported. Some studies have associated the gouty diathesis, which can include hyperuricosuria, uric acid stones, and even full-blown gout with Paget's disease. This could be related to increased purine metabolism in bone cells.  
 
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