Paget Paget
Paget Paget
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  29  
Neoplastic Complications of Paget's Disease  
 
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  Sarcomatous degeneration is the most serious complication of Paget's disease of bone, however, it occurs in less than 1% of patients. Not all tumors are sarcomas; metastatic cancer has been seen to metastasize to pagetic bone, and hematologic malignancies may also occur. Occasionally Paget's disease can be complicated by benign or rarely malignant giant-cell tumors.  
 
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