Paget Paget
Paget Paget
  Educational Slide Program  

Nonspecific and Experimental Therapies for Paget's Disease of Bone  
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  Prior to 1970, analgesics were the only useful form of therapy for partial symptomatic relief of bone pain related to Paget's disease. Analgesics and NSAIDs are still used for quick symptomatic relief, but these drugs do nothing to prevent the progression of disease. NSAIDs may be effective against associated osteoarthritic pain. Plicamycin (Mithracin®) and gallium nitrate (Ganite®) are intravenous drugs approved for treatment of hypercalcemia of malignancy. These agents have been used in research studies for Paget's disease but are not FDA approved for this indication. They have been used in clinical practice primarily for patients resistant to approved agents.  
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